We went there in the morning from Florenc bus station. The bus trip took about 2.5 hours but once we walked into the city we just forgot how long we have been sitting in the bus. From the bus stop (at the train station) walking up the hill into the shoppping street and along the river to visit different colonard was fantastic experience. Don't miss the russian othodox church in the villa area and if you have time. Get the bus to climb up the hill to see the city from above. It was so heart-touching. There's a small restaurant with a swimming pool where you can swim and see the view of the whole Karlovy Vary.